Murray Bridge will keep its pedal prix race until at least 2027.
The city's council and the Australian Human-Powered Vehicle Super Series have agreed to extend the event's contract by 10 years.
The agreement took about 18 months of negotiation, and was signed by council chief executive officer Michael Sedgman and Australian International Pedal Prix chairman Andrew McLachlan at Sturt Reserve on Wednesday.
Mr McLachlan said the Murray Bridge race had become an icon and the pinnacle of the pedal prix calendar.
"Australian International Pedal Prix is delighted the event will continue to be held at Sturt Reserve," he said.
Mr Sedgman said the thousands of visitors the pedal prix brought to the Murraylands each year added significantly to the regional economy.
"Extending our relationship for another 10 years will build on this opportunity for local business and the community," he said.
"We are very pleased to welcome this event to our regional centre again in 2018 and for years to come."
The 2018 Murray Bridge pedal prix will be held on September 22 and 23.
Races are also being held at Mount Gambier, Loxton, Adelaide and Busselton, Western Australia this year.