Native plants and birds, such as the malleefowl and hooded plover, will be better protected from weeds and invasive predators thanks to a $3.25 million investment in the Coorong district.
The federal government will provide the money to the South East Natural Resources Management Board over five years so it can eradicate weeds such as boxthorns across a 35,000-hectare area and foxes from an area almost twice that size.
It will also carry out works that will protect the Coorong's sedges, salt marshes and fresh water soaks from introduced shrubs and herbivores.
The board will also plan to protect sites important to migratory shorebirds, better control feral cats, and revegetate the area surrounding the waterway.
Federal MP Tony Pasin and state Environment and Water Minister David Speirs visited Natural Resources South East's office near Meningie on Tuesday to announce the Our Coorong, Our Coast funding, which came as part of a $1 billion federal investment in Landcare programs.
Mr Pasin said the project would improve understanding of the coastal systems of the Coorong and Limestone Coast, and would engage with the community to improve its stewardship of the internationally significant ecosystem for future generations.