The state's road toll has hit 43 deaths, as of Monday, May 6, which is 14 more people who have died than the average number at the same time over the past five years.
This week is National Road Safety Week (NRSW) and the State Government, SA Police and the RAA are highlighting the need for drivers to be responsible for their behaviour on the road.
"Drive so others survive" is the message being highlighted this year.
Acting Premier Vickie Chapman said too many people had already lost their lives on South Australian roads this year.
"The impact of losing a life on our roads has a deep, distressing impact on communities," she said.
"Every life lost is a friend and family member.
"We want South Australians to take the pledge this NRSW to make the roads safer for everyone."
RAA road safety senior manager Charles Mountain said this year has had a high toll of road crash deaths and serious injuries.
"More than 40 lives have been lost and 128 people seriously injured in the first four months alone and these tragedies reinforce the importance of the road safety message,'' he said.
"Make sure you know and follow the road rules because breaking them can have devastating consequences for so many people.''
Mr Mountain also suggested the next Federal Government should adopt the 12 recommendations which resulted from last year's National Road Safety Strategy Inquiry.
"We welcome the Federal Government's promise to create a national Office of Road Safety, but we need real financial commitments from both the government and opposition including $3 billion a year towards a road safety fund," he said.
"A change in strategy is urgently needed to rid the nation of high-risk highways and stop the carnage on our roads."
National Road Safety Week will concluded on Sunday, May 12.